THE POTENTIAL OF STEM CELL THERAPY AS A MANAGEMENT OF CHRONIC PAIN: A SYSTEMATIC REVIEW

Background: Stem cells has previously been used with promising results as a therapeutic modality for neurodegenerative diseases and pain but recently introduced treatment chronic pain. Objective: This study aims to review the available literature on role of stem cell therapy Methods: A clinical reports using PRISMA (Preferred Reporting Items Systematic Review Meta-Analysis) method published in Pubmed, EMBASE (Excerpta Medica Database), ScienceDirect were from 2013 2023, The search tool was locate enroll patients ongoing, presently active studies. terms included “chronic pain,” “therapy,” “prosedure” “neuropathic,” “discogenic,” “modality,” “musculoskeletal” “stem cell.” research then carried out assess quality Critical Appraisal Skills Program questionnaire. Results: There around 186 studies related keyword, only about 11 that met inclusion criteria this article obtained. Based study, it found form MSC ADS, which used, had significant effect patients. decrease obtained based VAS (Visual Analog Scale), ODI (Oswestry Disability Index), NRS (Numeric Rating Scale) assessments well an increase patient function. Conclusion: Although current suggesting use mscs novel disc, neuropathic, musculoskeletal pain, further are required demonstrate efficacy security